Oleic acid reversibly opens the blood-brain barrier

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Oleic acid reversibly opens the blood-brain barrier.

This study examined the effect of intracarotid oleic acid infusion on blood-brain barrier permeability. Oleic acid was infused for 30 s at a rate of 6 ml/min into the right internal carotid artery at concentrations of 10(-6), 10(-5), 2 x 10(-5) and 5 10(-5) M. Extensive Evans blue-albumin extravasation was observed 15 min after the administration of 2 x 10(-5) M oleic acid. The permeability sur...

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ژورنال

عنوان ژورنال: Brain Research

سال: 1991

ISSN: 0006-8993

DOI: 10.1016/0006-8993(91)91326-v